Using Atlas Antibodies rabbit anti-XK (HPA019036) polyclonal antibody for McLeod Syndrome and Chorea-Acanthocytosis diseases research
February, 2022 (Laboratory of Biochemistry and Immunology, Osaka University, Japan)
The X-linked Kx Blood Group (XK) is a protein-coding gene associated with McLeod Syndrome and Chorea-Acanthocytosis diseases, both characterized by the progressive movement, cognitive and behavioral disorders.
At a cellular level, cell lysis and necrosis can be found in cells and blood-forming tissues.
Using our rabbit anti-XK (HPA019036) polyclonal antibody, this newly published study by Ryoden Yetal, (PNAS 2022) shows that XK, complexing with other proteins at the plasma membrane, mediates a phospholipid scrambling activity essential for maintaining homeostasis in the immune and nervous systems, thus limiting cell lysis and necrosis.