Rabbit polyclonal anti-ADPRHL2/ARH3 used to gain insights into chromatin regulation and human disease
September, 2021 (University of Copenhagen, Denmark)
ADP-ribosylation is a reversible post-translational protein modification that regulates numerous processes, including DNA damage repair and chromatin remodeling.
ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear.
Using our rabbit polyclonal anti-ADPRHL2/ARH3 (HPA027104), this study from the University of Copenhagen reports that the loss of ARH3 activity in patient-derived primary fibroblasts and glioblastoma cells results in the accumulation of ADPr, increased PARGi sensitivity, and PARPi resistance leading to highly toxicity to the cell and distinct (patho)physiological effects.