Our anti-TRPV2 in skin cancer research
Article: "The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential"
Representative confocal images of low confluency WM266.4 and 451Lu metastatic melanoma cells seeded on fibronectin-coated coverslips. Cell nuclei are depicted with DAPI in blue, TRPV2 in green, and indicated proteins (actin, paxillin, vinculin, or pY397-FAK) in red (scale bar = 20 μm). Insets are magnifications of the indicated area. Arrows indicate sites of colocalization. Image from Shoji KF et al. (EMBO, 2023).
Cutaneous malignant melanoma (CMM) is one of the most metastatic and therapy-resistant malignancies, incurable for many patients and, consequently, in great need of specifying the molecular mechanisms underpinning its metastatic dissemination.
Calcium (Ca2+) channels regulate specific steps in tumor progression. This study by Shoji KF et al. (EMBO, 2023) highlights a central role for the prominently expressed Ca2+-conducting TRPV2 channel during the dynamic process of melanoma cells metastatic dissemination and identified calpains as one of TRPV2's key functional targets in that context.
👉 👉 Our rabbit polyclonal anti-TRPV2 (HPA044993) was used to show that TRPV2 is essential for melanoma tumor cell migration and invasion.