Our anti-DLX5 Triple A polyclonal antibody in reproductive organs development research
August 2022 (University of Texas MD Anderson Cancer Center, Houston, United States)
The reproductive tract organs of mammals are derived from two pairs of epithelial tubes surrounded by mesenchyme called the Wolffian ducts (progenitor male reproductive tract) and Müllerian ducts (progenitor female reproductive tract).
Interestingly, both the Wolffian and Müllerian ducts are formed regardless of the genetic sex of the embryo.
Differential hormone signaling after the formation of these genital ducts results in Wolffian duct loss in female embryos and Müllerian duct regression in male embryos.
Müllerian duct regression in males is mediated by the TGF-β family member anti-Müllerian hormone (AMH) secreted by cells of the fetal testes.
This study by Mullen et al. (Front. Endocrinol., 15 July 2022) identifies a new pair of transcription factors Dlx5 and Dlx6 as redundant downstream effectors of Müllerian regression.
🔬Our rabbit anti-DLX5 Triple A polyclonal antibody (HPA005670) was used in immunofluorescence in cross-sections from E14.5 male (A) and female (B) embryos.
Read the whole article: ”Distal-less homeobox genes Dlx5/6 regulate Müllerian duct regression”.