Multiplexed selectivity screening of anti-GPCR antibodies

June 2023 (Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 171 65 Solna, Sweden)

The superfamily of heterotrimeric guanine-nucleotide-binding regulatory protein (G protein)–coupled receptors (GPCRs) comprises ~750 membrane proteins that mediate signaling pathways for many aspects of cellular physiology and intercellular communication.

Anti-GPCR antibodies have emerged as a key enabling tool in many bioanalytical methods to study the biology and molecular pharmacology of GPCRs.

Read how a multiplexed immunoassay helped to test over 400 anti-GPCR antibodies from the Human Protein Atlas (manufactured by Atlas Antibodies) targeting a customized library of 215 GPCRs.