Four of our antibodies in glioma research

October 2022 (Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden)

The human brain's subventricular zone (SVZ) is a source of adult stem cells and a microenvironment for Neural Stem Cells. The SVZ has been studied in relation to glioblastomas but not as much in IDH-mutated diffuse lower-grade gliomas.

👉 The question researchers wanted to answer was: do IDH-mutated lower-grade gliomas in contact with SVZ show differential expression of stem cell markers compared to IDH-mutated lower-grade gliomas without SVZ contact?

To answer the question, an exploratory study by Corell et al. (Neuro-Oncology Advance, 2022) used 4 of our antibodies, as stemness markers, on tissue microarrays of tumor samples from patients diagnosed with diffuse lower-grade gliomas:
polyclonal anti-CD133 (HPA004922)
polyclonal anti-Nestin (HPA026111)
polyclonal anti-KLF4 (HPA002926)
monoclonal anti-SOX9 (AMAb90795)

The results showed intersample variability of SOX2, SOX9, Nestin, and Ki67 expression. However, no difference was found between tumors with or without SVZ contact, suggesting that the potential impact of SVZ on IDH-mutated diffuse lower-grade gliomas is probably not associated with a more stemness-like tumor profile.

Read the whole article here.

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