Anti-MUC5B rabbit polyclonal in SARS-CoV-2 research
July 2022 (Department of Biomedical Sciences, University of North Dakota School of Medicine & Health Sciences, Grand Forks, North Dakota, USA)
SARS-CoV-2 preferentially infects goblet cells in the bronchial airway epithelium. Goblet cells are a specialized type of epithelial cell that secrete mucins (MUCs), significant mucus components.
A study by Jaspreet Osan et al. (2022) from the University of North Dakota, USA, used our anti-MUC5B rabbit polyclonal (HPA008246; dil. 1:500) in fluorescence imaging to stain the apical site of the airway epithelium.
The results reveal that goblet cells play a critical role in SARS-CoV-2-induced pathophysiology in the lung.
Read the research paper here:
Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease (asm.org)
The image shows the immunofluorescence detection of MUC5B-positive goblet cells (anti-MUC5B, cyan) and SARS-CoV-2 N (anti-N, green); DAPI (blue). The arrows indicate SARS-CoV-2-infected nonciliated MUC5B-positive goblet cells.
Find the polyclonal Anti-MUC5B antibody used in the research at this link:
Rabbit Polyclonal Anti-MUC5B Antibody - Buy for research - Atlas Antibodies