Anti-LRBA polyclonal antibody in a study ”Regulation of CTLA-4 recycling by LRBA and Rab11”

May, 2021 (Institute of Immunity and Transplantation, University College London, United Kingdom)

Cytotoxic T-lymphocyte-associated protein 4, also known as CTLA-4 or CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses.

Defects in CTLA-4 trafficking due to LRBA deficiency cause profound autoimmunity in humans.


By using our anti-LRBA polyclonal antibody (HPA019366), this study plays with LRBA and CTLA-4 expression to determine how this protein affects CTLA-4 trafficking, thus providing an enhanced view of the critical relationship between CTLA-4 trafficking and LRBA.

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