Anti-FLNB Triple A polyclonal antibody used for the IHC staining within pancreatic ductal adenocarcinoma tissue
Wiedenmann S, Breunig M, Merkle J, von Toerne C, Georgiev T, Moussus M, Schulte L, Seufferlein T, Sterr M, Lickert H, Weissinger SE, Möller P, Hauck SM, Hohwieler M, Kleger A, Meier M. Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. Nat Biomed Eng. 2021 Aug;5(8):897-913. doi: 10.1038/s41551-021-00757-2.
Researchers have developed a method for creating in vitro models of diseases affecting the pancreatic ductal compartment.
A microwell chip for generating and culturing 3D cell aggregates.
The study explores a novel approach for generating pancreatic duct-like organoids from human induced pluripotent stem cells (iPSCs).
Using a microwell chip system, the researchers were able to achieve precise, single-cell resolved differentiation of iPSCs into functional pancreatic duct-like structures.
The authors induced the differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids. By analyzing the gene expression and imaging the forming organoids at the single-cell level over time, they identified the developmental trajectories of various cell types within the pancreas.
These pancreatic duct-like organoids expressed markers and exhibited similarities to human adult duct cells. Overall, this microsystem could help to create personalized pancreatic-duct models for studying disease mechanisms.
This platform allowed for the controlled microenvironment necessary to closely mimic the in vivo developmental processes of the pancreas.
The work contributes to the field of regenerative medicine, offering a potential model for studying pancreatic diseases and developing therapeutic strategies, including cell-based treatments for diabetes.
🔬Our anti-FLNB Triple A polyclonal antibody (HPA004886) was used for the IHC staining within pancreatic ductal adenocarcinoma tissue.