April 2023 (Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.).

Parkinson's disease is a neurodegenerative disorder that affects movement. It occurs due to low levels of dopamine in the area of the brain that facilitates movement (substantia nigra, pars compacta). Without sufficient dopamine, the brain is unable to transmit signals to correctly coordinate movement.

Featured in this study is our Anti-SOX6 (HPA001923) TripleA Polyclonal antibody used in multiplexed IHC-IF. 

March 2023 (The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, People’s Republic of China).

Patchouli alcohol: a promising natural treatment of Alzheimer’s disease?

Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease. Featured in this study is our TripleA Polyclonal anti-GFAP (HPA056030). 

March 2023 (INSERM, Rennes, France).

Our rabbit polyclonal anti-TRPV2 (HPA044993) was used to show that TRPV2 is essential for melanoma tumor cell migration and invasion.

Shoji KF et al. The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential. EMBO Rep. 2023 Feb 6:e55069.

February 2023 (National Yang-Ming Chiao Tung University, Taipei, Taiwan).

A novel combined therapeutic option for the treatment of colorectal cancer?

Chang YC, et al, Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells. Mol Oncol. 2023 Jan 18.

January 2023 (St. Jude Children’s Research Hospital, Memphis, USA).

Loss of ZBTB18 promotes metastasis: this study explores the role of the transcriptional repressor ZBTB18 in metastatic mechanisms.

Wang R, et al. ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis. Sci Adv. 2023 Jan 6;9(1):eabq3951. 

January 2023 (the Clinical Proteomic Tumor Analysis Consortium, USA).

This study enhances our understanding of kidney cancer, a complex and heterogeneous disease, by utilizing various analytical approaches.

Li Y, et al. Clinical Proteomic Tumor Analysis Consortium.
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness. Cancer Cell. 2023 Jan 9;41(1):139-163.e17.

January 2023 (Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, 06030, USA)

Sideroflexin 4 is overexpressed in ovarian cancer tissue and ovarian cancer cell lines.

Tesfay, L., Paul, B.T., Hegde, P. et al. Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer. Sci Rep 12, 19936 (2022).

December 2022 (Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany).

New findings help build a model for the specific role of FGFR2b signalling on distal epithelial progenitors during pseudo-glandular lung development.

Jones, M.R., Lingampally, A., Ahmadvand, N. et al. FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Cell. Mol. Life Sci. 79, 609 (2022)

December 2022 (Department of Pathology GROW School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands)

November 2022 (Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany)

November 2022 (Division of Cellular Signaling, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan)

November 2022 (Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea)

TMED9 (transmembrane emp24 domain-containing protein 9), which regulates the innate immune system and the protein transport via the ER-Golgi cargo pathway, has been implicated in various cancer types.

Han GH et al., TMED9 Expression Level as a Biomarker of Epithelial Ovarian Cancer Progression and Prognosis. Cancer Genomics Proteomics. 2022 Nov-Dec;19(6):692-702. 

October 2022 (Department of Neurosurgery, Yonsei University College of Medicine, Seoul, South Korea)

October 2022 (Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden)

October 2022 (Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada)

Napsin-A and AMACR are superior to HNF-1β in distinguishing between mesonephric carcinomas and clear cell carcinomas of the gynecologic tract.

Mesonephric carcinomas are rare malignant tumors of the female uterine cervix commonly mistaken for an ovarian clear cell carcinoma due to their overlapping morphologic features.

September 2022 (Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany)

Neuroscience: Ketogenic diet uncovers differential metabolic plasticity of brain cells.

The ketogenic diet is a low-carbohydrate, high-fat regime in which ketone bodies are utilized instead of glucose as an energy source.

September 2022 (The FIRC Institute of Molecular Oncology (IFOM), Milan, Italy)

The histone landscape in humans is complex: while there is only one histone H4 protein, diverse variants exist for H2A, H2B, and H3.

September 2022 (Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, USA)

August 2022 (University of Texas MD Anderson Cancer Center, Houston, United States)

The reproductive tract organs of mammals are derived from two pairs of epithelial tubes surrounded by mesenchyme called the Wolffian ducts (progenitor male reproductive tract) and Müllerian ducts (progenitor female reproductive tract).

August 2022 (School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China)

Mitochondria's contribution to inflammatory responses.

August 2022 (Department of Clinical Medicine, University of Bergen, 5021, Bergen, Norway)

August 2022 (Shanghai Jiao Tong University School of Medicine, China)

Schwann cells facilitate wound healing by releasing TGF-β3.

July 2022 (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China)

Squamous cell carcinomas show a specific expression pattern of TMTC3. Moreover, high expressions of TMTC3 are associated with poor survival in esophageal squamous cell carcinomas patients.

July 2022 (Department of Biomedical Sciences, University of North Dakota School of Medicine & Health Sciences, Grand Forks, North Dakota, USA)

SARS-CoV-2 preferentially infects goblet cells in the bronchial airway epithelium. Goblet cells are a specialized type of epithelial cell that secrete mucins (MUCs), significant mucus components.

July 2022 (Max Planck Institute for Molecular Genetics, Berlin, Germany)

June 2022 (Nagoya City University Graduate School of Medical Sciences, Japan)

TINAGL1: a promising candidate biomarker and therapeutic target in breast cancer patients.

June 2022 (Sanger Institute, Hinxton, Cambridgeshire, United Kingdom)

May 2022 (Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea)

May 2022 (Department of General Surgery, Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, China)

Using our Anti-ANLN polyclonal antibodies (HPA005680, HPA050556) this comprehensive analysis (Yanlong Shi, et al. 2022) reveals the carcinogenic and immunological roles of ANLN in human cancers. 

May 2022 (Technology Innovation Lab, New York Genome Center, USA)

"An open source toolkit for repurposing Illumina sequencing systems as versatile fluidics and imaging platforms".

Fluorescence microscopy is a crucial method in the life sciences. It requires automated execution to generate robust and reproducible data.

Accessibility to software, hardware, and protocol open platforms is therefore necessary to facilitate analysis and programmable applications without specialized engineering or software development expertise.

May 2022 (Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China)

April 2022 (German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany)

Mitochondrial energy production is finely tuned to interpret cellular needs accurately.

April 2022 (Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Greece)

RNF113A (Ring Finger Protein 113A) regulates survival and differentiation properties of neural stem cells.

April 2022 (Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia)

Malignant melanoma is the most severe type of skin cancer with the highest mortality rate.

April 2022 (Institute of Pharmaceutical Sciences, Zurich, Switzerland)

March 2022 (Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, USA)

Lung cancer: deregulation of the ubiquitin-proteasome system promotes suppression of innate immunity, which fosters lung cancer immune evasion.

March, 2022 (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria)

Muscle degeneration (or muscle atrophy) is the wasting or thinning of muscle mass that leads to frailty and dependency in inherited diseases and aging, affecting hundreds of millions of people.

March, 2022 (Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy)

February, 2022 (Laboratory of Biochemistry and Immunology, Osaka University, Japan)

February, 2022 (Department of Pathology and Medical Biology, University Medical Center Groningen, Netherlands)

January, 2022 (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, China)

November, 2021 (Department of Clinical Medicine, College of Medicine, Hunan University of Chinese Medicine, China)

November, 2021 (Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, China)

September, 2021 (Department of Clinical Medicine - Department of Haematology, Aarhus, Denmark)

Novel putative protein biomarkers for colorectal cancer (CRC) identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with future  diagnostic potential.

September, 2021 (University of Copenhagen, Denmark)

ADP-ribosylation is a reversible post-translational protein modification that regulates numerous processes, including DNA damage repair and chromatin remodeling.

August, 2021 (Division of Oncology and Therapeutic Pathology, Department of Clinical Sciences, Lund University, Sweden)

Treatment options for patients with pancreatic cancer are limited, and chemotherapy remains the standard of care, leading to only modest survival benefits.

August, 2021 (Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China)

July, 2021 (Molecular and Cellular Pharmacology Graduate Training Program, University of Wisconsin-Madison, USA)

June, 2021 (Department of Pediatric Immunology, Hacettepe University Medical School, Ankara, Turkey)

June, 2021 (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea)

May, 2021 (Division of Oncology, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Sweden)

May, 2021 (Institute of Immunity and Transplantation, University College London, United Kingdom)

Cytotoxic T-lymphocyte-associated protein 4, also known as CTLA-4 or CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses.

April, 2021 (Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan)

April, 2021 (Institute for Research in Biomedicine, Barcelona, Spain)

The capacity to repair damaged DNA may modulate individual susceptibility to develop lung cancer.

April, 2021 (Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht, Netherlands)

Treatment options for patients with lacrimal gland disorders are limited partly due to a lack of biological understanding.

April, 2021 (Department of Biology, University of Waterloo, Ontario, Canada)

March, 2021 (Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Finland)

March, 2021 (Hopp Children’s Cancer Center Heidelberg, Germany)

March, 2021 (Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan)

February, 2021 (Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, USA)