Anti-DNAJB9 Antibody

Product Features

The Anti‑DNAJB9 antibody (HPA041553) is a high‑quality, affinity‑purified rabbit polyclonal antibody developed within the Human Protein Atlas project and designed for precise detection of DNAJB9 (DnaJ/Hsp40 homolog, subfamily B, member 9)—an endoplasmic reticulum‑associated co‑chaperone involved in protein folding and cellular stress responses. Validated primarily for immunohistochemistry (IHC), this antibody demonstrates moderate granular cytoplasmic staining in human testis, particularly within seminiferous ducts, consistent with the ER‑linked localization observed in cell models. These patterns align with independent characterization, including immunofluorescence data showing ER and cytosolic localization in human fibroblast cell lines.

Significance in Research:

DNAJB9 encodes an ER‑resident Hsp40‑family co‑chaperone, a key participant in protein quality control. It plays essential roles in:

1. ER Stress Response & Protein Homeostasis DNAJB9 assists in folding newly synthesized polypeptides and modulating ER stress pathways via interaction with chaperone networks. Its role in cellular proteostasis makes it an important target in studies of ER‑associated degradation (ERAD) and stress‑linked pathologies.
2. Disease-Relevant Mechanisms Recent research highlights DNAJB9 in pathological misfolding processes, such as those linked to mutant CFTR (ΔF508‑CFTR), where modulation of DNAJB9 expression influences protein rescue strategies—an emerging therapeutic interest.
3. Cancer & Tissue‑Specific Expression DNAJB9 is broadly expressed across human tissues. Its IHC characterization across 44 normal tissues and 20 cancer types provides rich annotation for cancer pathology, molecular diagnostics research, and ER‑stress‑associated oncogenic pathways.