Dilution: 1:1000 - 1:2500
Retrieval method: HIER pH6
Validation of protein expression in IHC by comparing independent antibodies targeting different epitopes of the protein.
Validated against independent antibody Anti-TMEM119 HPA052650.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
J Clin Invest , 2018 Oct 29; 128(12):5399-5412. Epub 2018 Oct 29
TMEM119 silencing inhibits cell viability and causes the apoptosis of gastric cancer SGC-7901 cells
Oncol Lett , 2018 Mar 28; 15(6):8281-8286. Epub 2018 Mar 28
Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts
Brain Pathol , 2017 Dec 28; 28(6):791-805. Epub 2017 Dec 28
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases
Immunity , 2017 Sep 19; 47(3):566-581.e9
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Nature Neuroscience , July 03, 2017
Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
Brain , 2017 May 24; 140(7):1900-1913. Epub 2017 May 24
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