Anti-TMEM119 Antibody

Highest antigen sequence identity to the following orthologs:
Mouse ENSMUSG00000054675 (52%)
Rat ENSRNOG00000000700 (46%)
Recommended conditions:
Dilution: 1:500 - 1:1000
Retrieval method: HIER pH6
Validation of protein expression in IHC by comparing independent antibodies targeting different epitopes of the protein.
Validated against independent antibody Anti-TMEM119 HPA052650.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
All characterization data for ENSG00000183160 on the Human Protein Atlas
Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation
Brain Pathol , 2020 Jun 26; 30(5):897-912. Epub 2020 Jun 26
Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment
Acta Neuropathol Commun , 2019 Dec 11; 7:206. Epub 2019 Dec 11
Microglia express TMEM119 in the brains of Nasu-Hakola disease
Intractable Rare Dis Res , 2019 Nov; 8(4):260-265
A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
Brain , 2019 Oct 3; 142(11):3440-3455. Epub 2019 Oct 3
Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry
eLife , 2019 Aug 1; 8:e48051. Epub 2019 Aug 1
Microglia damage precedes major myelin breakdown in X‐linked adrenoleukodystrophy and metachromatic leukodystrophy
Glia , 2019 Feb 11; 67(6):1196-1209. Epub 2019 Feb 11
Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes
Immunity , 2018 Nov 21; 50(1):253-271.e6. Epub 2018 Nov 21
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
J Clin Invest , 2018 Oct 29; 128(12):5399-5412. Epub 2018 Oct 29
TMEM119 silencing inhibits cell viability and causes the apoptosis of gastric cancer SGC-7901 cells
Oncol Lett , 2018 Mar 28; 15(6):8281-8286. Epub 2018 Mar 28
Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts
Brain Pathol , 2017 Dec 28; 28(6):791-805. Epub 2017 Dec 28
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases
Immunity , 2017 Sep 19; 47(3):566-581.e9
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Nature Neuroscience , July 03, 2017
Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
Brain , 2017 May 24; 140(7):1900-1913. Epub 2017 May 24
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