Anti-DZANK1 Antibody

Product Features

The Anti‑DZANK1 antibody (HPA064255) is a high‑quality, affinity‑purified rabbit polyclonal antibody developed within the Human Protein Atlas initiative for selective detection of DZANK1 (Double Zinc Ribbon and Ankyrin Repeat Domains 1), a protein characterized by multiple zinc‑binding motifs and ankyrin repeats that suggest roles in protein‑protein interactions and regulatory signaling. Validated for immunocytochemistry–immunofluorescence (ICC‑IF) and Western blot (WB), this antibody demonstrates reliable detection across diverse human samples, including RT‑4 and U‑251 MG cell lines, as well as human plasma, liver, and tonsil tissues. Enhanced validation further strengthens confidence in specificity and performance across applications.

Significance in Research:

Although DZANK1 remains a relatively understudied protein, its double zinc‑ribbon domains and ankyrin repeat motifs point toward functional roles in protein scaffolding, molecular assembly, and cellular regulation. The availability of a validated, high‑specificity antibody enables researchers to:

1. Explore Protein Complex Formation & Signaling Pathways DZANK1’s structural domains are typically associated with regulatory protein‑protein interactions. The antibody supports WB‑based mapping of protein partners and ICC‑IF studies to visualize spatial distribution within cells.
2. Investigate Tissue‑Specific Expression and Physiological Roles The protein’s detection in diverse human tissues (including liver, plasma, and tonsil) suggests involvement in multiple physiological contexts. HPA064255 provides a reliable tool for profiling DZANK1 expression patterns in health and disease models.
3. Enable Cross‑Species Comparative Biology Given the 90% sequence conservation with rodent orthologs, this antibody facilitates translational studies connecting human findings to animal disease models.