Anti-ZNF503 Antibody

Product Features

The Anti‑ZNF503 antibody (HPA026848) is a high‑quality, affinity‑purified rabbit polyclonal antibody developed within the Human Protein Atlas project for the selective detection of ZNF503, a zinc finger transcription factor implicated in developmental gene regulation and cell‑state transitions. Validated for immunocytochemistry, immunofluorescence (ICC‑IF) and Western blot (WB), the antibody delivers robust and reliable performance across human cell models. Western blot characterization demonstrates clear detection of ZNF503 in PC‑3 and MCF‑7 cell lines, supported by orthogonal RNA‑seq expression comparisons to confirm specificity. Enhanced validation further increases confidence in assay reliability across applications. 

Significance in Research:

Although ZNF503 remains an emerging research focus, accumulating evidence points to important regulatory functions in development, transcriptional repression, and lineage specification. Access to a well‑validated antibody like HPA026848 enables researchers to investigate these roles with confidence.

1. Transcriptional Regulation & Lineage Control - ZNF503 is predicted to function as a transcriptional repressor, consistent with its C2H2‑type zinc‑finger motif. This makes the antibody a valuable tool for mapping ZNF503‑mediated transcriptional networks, especially in studies involving neural development, tissue patterning, or stem‑cell differentiation.
2. Molecular Profiling in Cancer and Developmental Biology - The antibody’s validated WB and ICC‑IF performance in PC‑3 and MCF‑7—models relevant to prostate and breast cancer—supports exploration of ZNF503 expression dynamics in tumor biology. Orthogonal validation using RNA‑seq further ensures that observed protein signals reflect true biological expression, enabling high‑confidence comparative studies across developmental and disease contexts.
3. Cross‑Species Translational Studies - With 92% ortholog identity in rodent species, the antibody is well suited for cross‑species experimental pipelines, including mouse genetic models, organoid systems, and in vivo developmental studies.