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Anti-HIF1A Antibody
Polyclonal Antibody against HUMAN HIF1A
0.2 mg/ml
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm & nuclear bodies.
The Anti‑HIF1A antibody (HPA000907) enables sensitive detection of HIF1A (Hypoxia‑inducible factor 1α), a core transcription factor regulating cellular responses to low oxygen. According to the Human Protein Atlas, HIF1A is classified as a cancer‑related, disease‑related, metabolic, and plasma protein, reflecting its broad significance in tumor biology, cellular metabolism, and stress signaling.
Significance in Research: HIF1A shows tissue‑enhanced RNA expression in bone marrow, clustering with genes involved in nuclear processes, and displays mainly nuclear expression at the protein level, with additional cytoplasmic presence and rare chromosome‑aligned expression in specific cell subsets. Subcellular localization is centered in the nucleoplasm and nuclear bodies, consistent with its transcription‑factor function. This antibody is ideal for research in hypoxia signaling, tumor microenvironment adaptation, inflammatory responses, and metabolic reprogramming, offering strong support for studies exploring how cells sense and respond to low‑oxygen stress.
Alternative antibodies
Corresponding antigens
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From our facilities in Stockholm, Sweden we develop, manufacture and distribute highly advanced reagents to the Life Sciences community worldwide.
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Learn how we validate our antibodies, how we secure their reproducibility, and why we apply enhanced validation. Our antibodies are validated in IHC, ICC-IF, and WB.