Our anti-NECAB1 in diabetes mellitus research

Udagawa, H., et al. Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells. Sci Rep 13, 17958 (2023).

Type 2 diabetes mellitus (T2D) is a metabolic disorder characterized by insulin resistance, impaired glucose regulation, and elevated blood sugar levels. Glucocorticoid receptors, which are proteins that bind to the stress hormone cortisol, play a role in glucose metabolism and may be associated with the pathology of T2D.

Insulin secretion in pancreatic β-cells is a crucial process in glucose homeostasis, and its dysregulation plays a significant role in the development and progression of T2D.

Individuals with T2D, show abnormalities in glucocorticoid receptor signaling and function. This can contribute to insulin resistance, affecting the body's ability to respond to insulin properly.

Understanding the relationship between T2D and glucocorticoid receptor markers is crucial for unraveling the complex mechanisms underlying the development and progression of this metabolic condition.

A new study published in Scientific Reports used our anti-NECAB1 (HPA025963) Triple A polyclonal antibody to show how the glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells.

Read the full article here.