Huntington's disease (HD) is an incurable neurodegenerative disease characterized by selective loss of specific neuronal populations leading to motor, cognitive, and psychiatric impairments.
A new study (bioRxiv, preprint) explores the transcriptomic and proteomic analysis of post-mortem brain tissue from multiple brain regions of HD patients and control donors.
🔬 By utilizing multiplex IHC-IF with our anti-MT3 (HPA004011) and anti-FABP7 (HPA028825) Triple A polyclonal antibodies, the authors were able to gain insight into the neuron-astrocyte-microglia interactions that could explain how this disease develops.
Overall, the results identified an astrocytic phenotype (enriched in less vulnerable brain regions) that can be leveraged to protect neurons in HD.