Tumor Proliferation Markers

Abnormal proliferation is a cardinal feature of cancer, needed for tumor development and progression. The processes that restrain normal regulated cell growth are often compromised or lost in cancer.

Hyperproliferation is often triggered by constitutively activated signal transduction pathways that promote uncontrolled proliferation. These include growth factor signaling pathways mediated by for example tyrosine kinase receptors such as EGFR, PDGFR, IGF-1R, Wnt, Bcr-Abl, and PI3K/Akt.

The increased proliferation rate of cancer cells makes them particularly sensitive to cytostatic agents.

Staining of Anti-ESR antibody (AMAb90867)
Left: IHC staining of human breast cancer using the Anti-ESR1 antibody (AMAb90867), shows strong nuclear immunoreactivity in a subset of tumor cells. Middle: WB analysis in MCF7 cells transfected with control si_RNA, target-specific siRNA probe, using the same Anti-ESR1 antibody. Right: ICC-IF staining of MCF7 cells using the same Anti-ESR1 antibody, showing specific staining in the nucleoplasm in green. Microtubules are visualized in red.
Mechanisms in Cancer

Mechanisms in Cancer

Download our white paper to learn about the mechanisms in cancer and protein markers used in cancer research.

 

 

Download white paper

Antibodies targeting tumor proliferation markers

Atlas Antibodies offer a range of primary antibodies targeting tumor proliferation markers. Selected antibodies are listed below.

IHC staining of breast duct carcinoma using Anti-HER2 antibody
IHC staining of breast duct carcinoma using the Anti-HER2 antibody (AMAb90627) showing strong positivity in tumor cells.

Anti-HER2 monoclonal antibody (AMAb90627)

  • validated for IHC, WB
  • sequence identity mouse/rat 84%/85%

Anti-HER2 monoclonal antibody (AMAb90628)

  • validated for IHC, WB, ICC-IF 
  • sequence identity mouse/rat 84%/85%

Anti-HER2 polyclonal antibody (HPA001383)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 82%/81%

Anti-ABL1 polyclonal antibody (HPA028409)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat 75%/77%

Anti-BRAF monoclonal antibody (AMAb91257)

  • validated for IHC, WB
  • sequence identity mouse/rat 93%/92%

Anti-BRAF monoclonal antibody (AMAb91258)

  • validated for IHC, WB
  • sequence identity mouse/rat 93%/92%

Anti-BRAF polyclonal antibody (HPA001328)

  • validated for IHC, WB
  • sequence identity mouse/rat 93%/92%

Anti-BRAF polyclonal antibody (HPA071048)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat 100%/100%

Anti-CSF1R polyclonal antibody (HPA012323)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 58%/61%

Anti-EGFR monoclonal antibody (AMAb90816)

  • validated for IHC, WB
  • sequence identity mouse/rat 90%/91%

Anti-EGFR polyclonal antibody (HPA018530)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 84%/82%

Anti-ERBB3/HER3 polyclonal antibody (HPA045396)

  • validated for IHC, WB
  • sequence identity mouse/rat 78%/77%

Anti-ESR1 monoclonal antibody (AMAb90867)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 88%/87%

Anti-FLT1 monoclonal antibody (AMAb90703)

  • validated for IHC
  • sequence identity mouse/rat 80%/82%

Anti-FLT1 monoclonal antibody (AMAb90704)

  • validated for IHC, WB
  • sequence identity mouse/rat 80%/82%

Anti-FLT4 polyclonal antibody (HPA067906)

  • validated for IHC
  • sequence identity mouse/rat 75%/74%

Anti-FOS polyclonal antibody (HPA018531)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat 94%/94%

Anti-JUN polyclonal antibody (HPA059474)

  • validated for ICC-IF
  • sequence identity mouse/rat 97%/95%

Anti-KIT polyclonal antibody (HPA004471)

  • validated for IHC
  • sequence identity mouse/rat 66%/72%

Anti-KIT  monoclonal antibody (AMAb90901)

  • validated for IHC, WB
  • sequence identity mouse/rat 66%/72%

Anti-MKI67 monoclonal antibody (AMAb90870)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat 68%/68%

Anti-MYC polyclonal antibody (HPA055893)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat 92%/89%

Anti-MYCN polyclonal antibody (HPA057420)

  • validated for ICC-IF
  • sequence identity mouse/rat 87%/87%

Anti-NFKB2 polyclonal antibody (HPA008422)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 93%/92%

Anti-NFKB2 polyclonal antibody (HPA023900)

  • validated for IHC, WB
  • sequence identity mouse/rat 96%/96%

Anti-PCNA polyclonal antibody (HPA030522)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 99%/100%

Anti-PDGFRB polyclonal antibody (HPA028499)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat 76%/76%

Anti-PGR monoclonal antibody (AMAb91529)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat 67%/68%

Anti-PTEN polyclonal antibody (HPA031335)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat 100%/100%

Anti-SMAD2 monoclonal antibody (AMAb91520)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 94%/94%

Anti-SMAD3 polyclonal antibody (HPA046386)

  • validated for ICC-IF
  • sequence identity mouse/rat 100%/100%

Anti-SMAD3 polyclonal antibody (HPA067203)

  • validated for IHC, WB
  • sequence identity mouse/rat 100%/100%

Anti-SMAD4 polyclonalantibody (HPA019154)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 94%/95%

Anti-SMAD4 monoclonal antibody (AMAb91594)

  • validated for IHC, WB
  • sequence identity mouse/rat 94%/95%

Anti-SMAD7 polyclonal antibody (HPA028897)

  • validated for IHC, ICC-IF
  • sequence identity mouse/rat 99%/99%

Anti-TGFA polyclonal antibody (HPA042297)

  • validated for IHC
  • sequence identity mouse/rat 93%/93%

Anti-TGFB1 polyclonal antibody (HPA017019)

  • validated for IHC, WB
  • sequence identity mouse/rat 88%/87%

Anti-VEGFA polyclonal antibody (HPA069116)

  • validated for IHC
  • sequence identity mouse/rat 86%/88%