Our anti-FOXP2 used to better understand the organization of mouse mPFC

Nagy-Pál P, Veres JM, Fekete Z, Karlócai MR, Weisz F, Barabás B, Reéb Z, Hájos N. Structural Organization of Perisomatic Inhibition in the Mouse Medial Prefrontal Cortex. J Neurosci. 2023 Oct 18;43(42):6972-6987.

The medial part of the prefrontal cortex (mPFC) contains two types of basket cells: PV-expressing basket cells (PVBCs) and CCK-expressing basket cells (CCKBCs), which have distinct morphological characteristics and play different roles in controlling neural activity within and across the different layers of the mPFC.

PVBCs regulate pyramidal cell operation in a layer-specific manner, while CCKBCs provide cross-layer inhibition in the mPFC.

The study classifies the mPFC layers using immunostaining with a combination of antibodies such as anti-Calb and the transcription factors anti-WFS1, anti-Ctip2, and anti-FOxP2.

Our mouse anti-FoxP2 (PrecisA Monoclonal AMAb91362) was used in multiplexed IHC-IF to specifically define mPFC layer 6.

These findings contribute to a better understanding of the organization and function of basket cell networks in the mPFC at the microcircuit level.

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