43 TripleA Polyclonals to explore the intricacies of the human stomach
Öling S, Struck E, Noreen-Thorsen M, Zwahlen M, von Feilitzen K, Odeberg J, Pontén F, Lindskog C, Uhlén M, Dusart P, Butler LM. A human stomach cell type transcriptome atlas. BMC Biol. 2024 Feb 14;22(1):36. doi: 10.1186/s12915-024-01812-5. PMID: 38355543; PMCID: PMC10865703.
The stomach, a vital part of our digestive system, has a unique environment that defends against microbes and helps digest food. Unlike other parts of the digestive tract, we lack detailed info on stomach cell genes.
A fascinating paper by Öling and colleagues at the Human Protein Atlas (BMC Biol. 2024) presents a transcriptome atlas, shedding light on the diverse cell types in our stomach.
Researchers analyzed data from 359 people, identifying 1600 genes specific to various cell types. The team employed 43 TripleA Polyclonal antibodies from Atlas Antibodies in immunohistochemistry (IHC), coupled with concurrent RNA sequencing and single-cell analysis.
Results show that non-coding genes are linked to gastric cancer and pinpoint genes found only in male chief cells. This study paves the way to better comprehend our stomach's biology.
Read the full article here.