White Papers and Brochures

Cancer stem cells (CSCs) drive the tumor’s initiation, growth, and metastasis, and may cause relapse. Due to their importance, several biomarkers that characterize CSCs have been identified, allowing diagnostic, therapeutic, and prognostic predictions. In this white paper, we provide an overview of the most prominent CSC markers, focusing on solid cancers and hematological cancers.

Neuroscience is the study of the nervous system and disorders and injuries that affect its functioning. Our neuroscience antibodies are highly validated and show high specificity and selectivity for their target proteins. They are tailored for use in research on signaling, neural lineage, developmental processes, aging, and neurodegenerative disorders in human and rodent tissue samples.

The tumor microenvironment (TME) is the environment around a tumor that profoundly influence tumor progression and metastatic processes. In this White Paper, you can read more about TME and cancer immunity markers.

This white paper provides an overview of how our antibodies are characterized and validated. Learn about antibody characterization and strategies for antibody validation. 

This paper presents the immunohistochemistry application, and how the tissue microarrays allow for large scale protein expression profiling within the Human Protein Atlas project. You can also read about how immunohistochemistry is used for subcellular protein profiling.

Subcellular localization studies are a key step in elucidating protein function and interaction. This paper introduces you on how to study subcellular localization with Triple A Polyclonals using Immunofluorescence analysis on cells.

Each Triple A Polyclonal is analyzed in 44 normal human tissues as well as in the 20 most common cancers using IHC. All proteins expression profiles are conveniently searchable online on the Human Protein Atlas portal. This White Paper shows how our antibodies are used for exploring the whole human body, and highlights selected publications published in high impact journals.

This White Paper offers advice on how to use loading control antibodies for your Western blot experiment and what to consider when choosing a loading control. 

The white paper demonstrates how the Triple A Polyclonals and PrecisA Monoclonals can be used for the detection of protein-protein interactions in human tissues in situ using a powerful PLA technique. Applications examples include Emerin-Lamins interactions in the nuclear membrane and interactions of E-cadherin and beta-catenin in the epithelial cell membrane. 

The neuroscience marker antibodies are designed to recognize the main anatomical and neurochemical cell types in rodent and human nervous system. This White Paper explains the design, development, validation, and applications of our antibodies. 

The cerebral cortex is the part of the human brain that undergoes the most profound evolutional changes and serves as a substrate for the higher cognitive functions. Learn about development and characteristics of cortical layers and about common markers for the different layers.

SOX proteins make up a family of high-mobility group (HMG) domain transcription factors implicated in a variety of physiological and pathological processes, including development, cell reprogramming, and tumorigenesis. So far, 20 different SOX genes have been discovered. This White Paper explains the role of the SOX family of proteins and presents antibodies targeting the SOX family members. 

A large number of our antibodies are relevant for scientists studying colorectal cancer. In this brochure, you can find antibodies related to the field of colorectal cancer research together with publication references.

Our antibodies are used by scientists working to understand breast cancer. In this brochure, you can find antibodies related to the field of breast cancer research together with publication references. 

This white paper presents different mechanisms in cancer, including cell cycle,  cell death, tumor proliferation, tumor angiogenesis, and metastasis. In addition, you will find selected primary antibodies targeting protein markers involved in the respective cancer processes. 

This white paper presents the useful glioma marker ATRX and suitable co-markers IDH1 and GFAP. You will also find information about antibodies targeting these proteins.

Together with our research partners in the Human Protein Atlas project, we are in a unique position to perform antibody-based biomarker discovery. This white paper provides an overview of a few selected biomarkers. 

The Epithelial to Mesenchymal Transition (EMT) antibody marker panel is a collection of mouse monoclonals targeting key EMT markers for cell junctions, cytoskeletal changes, transcription regulation, and migration/motility. This White Paper explains the design, development, and validation of the EMT marker antibodies.

Stem cells are the cells that have a capacity for self-renewal and differentiation into other cell types. Two major stem cell types are present in mammals, embryonic stem cells and adult stem cells. In this White Paper, you can learn about the different types of stem cells, which protein markers are used to identify them and see which antibodies can be used to detect these proteins.

Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. In this White Paper, you can learn about neural stem cell markers in the mammalian brain.

Mesenchymal stem cells (MSCs) are tissue stem cells. They are ‘multipotent’, implying that they can differentiate into more than one cell type in the body. In this White Paper, you can learn about the different mesenchymal stem cell markers.

Eukaryotic cells use histone proteins to store DNA in the form of chromatin. Chromatin consists of tightly packed nucleosomes, where each nucleosome particle is built of an octamer with pairs of the four core histones H3, H4, H2A, and H2B. In addition, the linker histone H1 links the nucleosomes together and plays a role in modifying chromatin density and folding. This White Paper explains the role of histones and presents antibodies targeting histones. 

This White Paper explains the design, development, and validation of the organelle marker antibodies and describes how subcellular localization studies can be performed. The markers can be used as references to stain and confirm the location of the protein of interest. 

Integrins are a family of transmembrane receptor proteins connecting the cytoskeleton and extracellular matrix. There are 18 alpha and 8 beta subunits, forming at least 24 distinct integrin heterodimers. This White Paper explains the function and structure of integrins and presents antibodies specifically targeting the different integrins.

The antibodies in the Laminin Marker panel are designed to identify specific laminin subunits present in a tissue of interest to further understand the roles and expression patterns of different laminins. This White Paper explains the design, development, and validation of the laminin marker antibodies and includes one example on how to perform the verification of subunit composition of laminins in tissue using multiplexed IHC with antibodies from the panel.