Dilution: 1:50 - 1:200
Retrieval method: HIER pH6
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Miro proteins prime mitochondria for Parkin translocation and mitophagy
EMBO J , 2018 Nov 30; 38(2):e99384. Epub 2018 Nov 30
Alpha-Synuclein Delays Mitophagy and Targeting Miro Rescues Neuron Loss in Parkinson’s Models
Acta Neuropathol , 2018 Jun 9; 136(4):607-620. Epub 2018 Jun 9
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy
eLife , 2018 Apr 20; 7:e32866. Epub 2018 Apr 20
Mechanism and regulation of the Lys6-selective deubiquitinase USP30
Nat Struct Mol Biol , 2017 Sep 25; 24(11):920-930. Epub 2017 Sep 25
Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits
J Cell Biol , 2016 Jul 4; 214(1):103-119
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane
Mol Biol Cell , 2016/02/01; 27(3):466-482
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites
J Biol Chem , 2016 Jan 8; 291(2):613-629. Epub 2015 Nov 9
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling
J Neurosci , 2015 Dec 2; 35(48):15996-16011
Mitotic redistribution of the mitochondrial network by Miro and Cenp-F
Nature Communications , 6, (2015)
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Nature , 2014 Jun 19; 510(7505):370-5. Epub 2014 Jun 4
Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase
J Biol Chem , 2014 May 23; 289(21):14569-14582. Epub 2014 Mar 26
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells.
Nat Methods , 2013 Apr; 10(4):315-23. Epub 2013 Feb 24
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.
Hum Mol Genet , 2012 Mar 15; 21(6):1299-311. Epub 2011 Nov 30
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