Dilution: 1:500 - 1:1000
Retrieval method: HIER pH6
Working concentration: 0.4 µg/ml
Fixation/Permeabilization: PFA/Triton X-100
Working concentration: 1-4 µg/ml
Validation of protein expression in WB by comparing independent antibodies targeting different epitopes of the protein.
Genetic validation in WB by siRNA knockdown.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy
EMBO Mol Med , 2018 Nov 2; 11(1):e9288. Epub 2018 Nov 2
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
J Cell Biol , 2017 Jul 3; 216(7):2027-2045
Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis
J Biol Chem , 2016 Aug 5; 291(39):20516-20529. Epub 2016 Aug 5
Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation
Nature , June 22, 2016
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness
J Cell Biol , 2015/10/26; 211(2):373-389
StAR Enhances Transcription of Genes Encoding the Mitochondrial Proteases Involved in Its Own Degradation
Mol Endocrinol , 2013 Dec 18; 28(2):208-224. Epub 2013 Dec 18
Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease.
J Proteome Res , 2009 Nov; 8(11):5069-79
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis
Neoplasia , 1/01/01; 18(4):242-252. Epub 2016 Apr 20
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