Dilution: 1:1000 - 1:2500
Retrieval method: HIER pH6
Working concentration: 0.4 µg/ml
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Recombinant expression validation in WB using target protein overexpression.
This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. The results are part of an ongoing effort to map the human proteome using antibodies.
Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa
Cell Tissue Res , 2016 Apr 5; 365:331-341. Epub 2016 Apr 5
The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease
Scand J Gastroenterol , 2015; 50(10):1241-1252. Epub 2015 May 15
The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer
Cancer Epidemiol Biomarkers Prev , 2014 Nov; 23(11):2328-2337. Epub 2014 Oct 10
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