Monoclonal Anti-SOX11 Antibody

SRY (sex determining region Y)-box 11
References (3)
Recommended Applications
Product Description
Monoclonal Antibody against Human SOX11
Open Datasheet
Price
$505.00
Product Number
AMAb90502
Unit Size
Concentration
Lot dependent
Availability
>10 in Stock
Ships
Ready to Ship
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[2 pictures]
Immunohistochemical staining of human mantle cell lymphoma shows moderate to strong nuclear positivity in tumor cells.
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[1 pictures]
Lane 1: Marker [kDa]
Lane 2: Negative control (vector only transfected HEK293T lysate)
Lane 3: SOX11 Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY418895)

Human Protein Atlas

View this protein on the Human Protein Atlas
Target Protein
SRY (sex determining region Y)-box 11
Target Gene
SOX11
Verified Species Reactivity
Human
Interspecies Information

Highest antigen sequence identity to the following orthologs:

Mouse ENSMUSG00000063632 (82%)

Rat ENSRNOG00000030034 (82%)

Clonality
Monoclonal
Clone ID
CL0143
Isotype
IgG2a
Host
Mouse
Buffer
40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Material Safety Data Sheet
Purification Method
Protein A purified
Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Unit Size
100 µl
Current Lot
Produced on demand. Contact support@atlasantibodies.com for more information.
Concentration
Product Data Sheet
Download data sheet
Immunohistochemistry (IHC)

Recommended conditions:

Dilution: 1:200 - 1:500

Retrieval method: HIER pH6

Western Blot (WB)

Recommended conditions:

Working concentration: 1 µg/ml

Protocols
View all protocols
Immunohistochemistry (IHC)
All IHC characterization data in 44 normal tissues and 20 cancers for AMAb90502 on the Human Protein Atlas
Western Blot (WB)

Validated in Western blot using relevant lysates (see Western blot application images above)

Protein Name
SRY (sex determining region Y)-box 11
Gene Name
SOX11
UniProt ID
P35716
Gene (Ensembl)
ENSG00000176887
Entrez Gene ID
Entrez gene: 6664
Shipping
Normally shipped at ambient temperature.
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Jatiani SS, Christie S, Leshchenko VV, Jain R, Kapoor A, Bisignano P, Lee C, Kaniskan HÜ, Edwards D, Meng F, Laganà A, Youssef Y, Wiestner A, Alinari L, Jin J, Filizola M, Aggarwal AK, Parekh S

SOX11 inhibitors are cytotoxic in mantle cell lymphoma

Clin Cancer Res , 2021 Jun 22; 27(16):4652-4663. Epub 2021 Jun 22

PubMed ID: 34158358 DOI: 10.1158/1078-0432.CCR-20-5039

Inmaculada Ribera-Cortada, Daniel Martinez, Virginia Amador, Cristina Royo, Alba Navarro, Silvia Beà, Eva Gine, Laurence de Leval, Sergio Serrano, Andrew Wotherspoon, Dolors Colomer, Antonio Martinez, Elías Campo

Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype

Modern Pathology , September 11, 2015

PubMed ID: 0 DOI: 10.1038/modpathol.2015.99

Soldini D, Valera A, Solé C, Palomero J, Amador V, Martin-Subero JI, Ribera-Cortada I, Royo C, Salaverria I, Beà S, Gonzalvo E, Johannesson H, Herrera M, Colomo L, Martinez A, Campo E

Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma.

Am J Surg Pathol , 2014 Jan; 38(1):86-93

PubMed ID: 24145648 DOI: 10.1097/PAS.0b013e3182a43996

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Alternative Antibodies
Anti-SOX11 (AMAb90501)
Anti-SOX11 (HPA000536)
Corresponding Antigens
PrEST Antigen SOX11 (APrEST76154)

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