Enhanced Validation

Monoclonal Anti-ACE2 Antibody

angiotensin I converting enzyme 2
References (5)
Recommended Applications
Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.
Product Description
Monoclonal Antibody against Human ACE2
Open Datasheet
Price
$505.00
Product Number
AMAb91262
Unit Size
Concentration
Lot dependent
Availability
>10 in Stock
Ships
Ready to Ship
Show all images
[6 pictures]
Immunohistochemistry analysis in human duodenum and tonsil tissues using AMAb91262 antibody. Corresponding ACE2 RNA-seq data are presented for the same tissues.
Show all images
[1 pictures]
Western blot analysis in human kidney tissue.

Human Protein Atlas

View this protein on the Human Protein Atlas
Target Protein
angiotensin I converting enzyme 2
Target Gene
ACE2
Verified Species Reactivity
Human
Interspecies Information

Highest antigen sequence identity to the following orthologs:

Mouse ENSMUSG00000015405 (74%)

Rat ENSRNOG00000031665 (46%)

Clonality
Monoclonal
Clone ID
CL4035
Isotype
IgG1
Host
Mouse
Buffer
The antibodies are delivered in 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Material Safety Data Sheet
Purification Method
Protein A purified
Notes
The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
Unit Size
100 µl
Current Lot
Produced on demand. Contact support@atlasantibodies.com for more information.
Concentration
Product Data Sheet
Download data sheet
Immunohistochemistry (IHC)

Recommended conditions:

Dilution: 1:20000 - 1:50000

Retrieval method: HIER pH6

Western Blot (WB)

Recommended conditions:

Working concentration: 1 µg/ml

Protocols
View all protocols
Immunohistochemistry (IHC)

Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

All IHC characterization data in 44 normal tissues and 20 cancers for AMAb91262 on the Human Protein Atlas
Western Blot (WB)

Validated in Western blot using relevant lysates (see Western blot application images above)

Protein Name
angiotensin I converting enzyme 2
Gene Name
ACE2
UniProt ID
Q9BYF1
Gene (Ensembl)
ENSG00000130234
Entrez Gene ID
Entrez gene: 59272
Shipping
Normally shipped at ambient temperature
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Lindskog C, Méar L, Virhammar J, Fällmar D, Kumlien E, Hesselager G, Casar-Borota O, Rostami E

Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain

J Proteome Res , . Epub 2022 Jul 28

PubMed ID: 35901083 DOI: 10.1021/acs.jproteome.2c00184

Dong W, Mead H, Tian L, Park JG, Garcia JI, Jaramillo S, Barr T, Kollath DS, Coyne VK, Stone NE, Jones A, Zhang J, Li A, Wang LS, Milanes-Yearsley M, Torrelles JB, Martinez-Sobrido L, Keim PS, Barker BM, Caligiuri MA, Yu J

The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus

J Virol , 2022 Jan 12; 96(1):e00964-21. Epub 2022 Jan 12

PubMed ID: 34668775 DOI: 10.1128/JVI.00964-21

Martin G, Wolf J, Lapp T, Agostini HT, Schlunck G, Auw-Hädrich C, Lange CA

Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissues

Sci Rep , 2021 Sep 27; 11:19140. Epub 2021 Sep 27

PubMed ID: 34580409 DOI: 10.1038/s41598-021-98709-y

Werion A, Belkhir L, Perrot M, Schmit G, Aydin S, Chen Z, Penaloza A, De Greef J, Yildiz H, Pothen L, Yombi JC, Dewulf J, Scohy A, Gérard L, Wittebole X, Laterre PF, Miller SE, Devuyst O, Jadoul M, Morelle J, Cliniques universitaires Saint-Luc (CUSL) COVID-19 Research Group10AboubakarFrankFAcidSouadSAminiNadiaNBaillySarahSBeauloyeChristopheCCastanares-ZapateroDiegoDCocheEmmanuelECollienneChristineCCornettePascalePDe BrauwerIsabelleIDechampsMélanieMDupriezFlorenceFFroidureAntoineAGarnirQuentinQGerberBernhardBGhayeBenoîtBGilardIsabelleIGohySophieSGrégoireCharlesCHantsonPhilippePJacquetLuc-MarieLMKabambaBenoitBKautballyShakeelSLanthierNicolasNLarbaouiFatimaFLiistroGiuseppeGMaesFrédéricFMontielVirginieVMwengeBennyBPierardSophieSPiletteCharlesCPouleurAnne CatherineACSogorbAmauryAStarkelPeterPRodriguez-VillalobosHectorHThomaMaximilienMVan CaeneghemOlivierOVancraeynestDavidD

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Kidney Int , 2020 Aug 10; 98(5):1296-1307. Epub 2020 Aug 10

PubMed ID: 32791255 DOI: 10.1016/j.kint.2020.07.019

Lange C, Wolf J, Auw‐Haedrich C, Schlecht A, Boneva S, Lapp T, Horres R, Agostini H, Martin G, Reinhard T, Schlunck G

Expression of the COVID‐19 receptor ACE2 in the human conjunctiva

J Med Virol , 2020 Jul 11; 92(10):2081-2086. Epub 2020 Jul 11

PubMed ID: 32374427 DOI: 10.1002/jmv.25981

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Alternative Antibodies
Anti-ACE2 (AMAb91259)
Anti-ACE2 (HPA000288)
Corresponding Antigens
PrEST Antigen ACE2 (APrEST74018)

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