Integrins and Integrin Antibodies

Integrins are receptors for the intracellular matrix. Here you can learn about the function and structure of integrins and find antibodies targeting the different integrins. 

Function and structure of integrins

Integrins are a family of transmembrane receptor proteins, connecting the cytoskeleton and extracellular matrix (ECM). They bind to ECM glycoproteins including collagens, fibronectins, laminins, and a number of cellular receptors. In addition, integrins function as signal transducers. The different integrins activate differential intracellular signaling pathways that control biological and cellular functions including cell adhesion, migration, proliferation, cell differentiation, and apoptosis.

ICC staining of WM-115 cells using monoclonal antibody Anti-ITGB8 (AMAb91467)
ICC staining of WM-115 cells using monoclonal antibody Anti-ITGB8 (AMAb91467) antibody, showing specific staining in the plasma membrane in green.

Integrin specificity

There are 18 alpha and 8 beta subunits, forming at least 24 distinct integrin heterodimers. Each heterodimer consists of a large extracellular domain, binding proteins in the extracellular environment, a single-membrane-spanning transmembrane domain, and a generally small intracellular cytoplasmic tail domain which forms links with the cytoskeletal elements. 

The specificity of integrin binding to ECM components including laminins, collagens, and fibronectin depends on the exposed extracellular domains of the alpha and beta integrin subunits. The integrin proteins are formed by two noncovalently bound alpha and beta subunits. 

A selection of antibodies targeting specific integrin subunits is presented below.  

Antibodies targeting integrin alpha subunits

Our integrin antibodies have been evaluated in one or more applications such as IHC, WB and ICC-IF. The table below shows selected antibodies targeting integrin alpha subunits. For more details on each antibody, click the respective link below and visit the product page.

ITGA1/CD49a : Anti-ITGA1 monoclonal antibody (AMAb91461)

ITGA1/CD49a : Anti-ITGA1 monoclonal antibody (AMAb91461)

  • Selected interaction partners: ITGB1, LAMA1
  • Involved in: cell adhesion, inflammation, fibrosis

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ITGA2/CD49b: Anti-ITGA2 monoclonal antibody (AMAb91469)​

ITGA2/CD49b: Anti-ITGA2 monoclonal antibody (AMAb91469)​

  • Selected interaction partners: ITGB1, LAMA1
  • Involved in: cancer growth/invasion

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ITGA3/CD49c: Anti-TGA3 monoclonal antibody (AMAb91446)​

ITGA3/CD49c: Anti-TGA3 monoclonal antibody (AMAb91446)​

  • Selected interaction partners: ITGB1, I TGB4, ITGB5
  • Involved in: Laminin-binding, cancer growth/invasion

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ITGA4/CD49d: Anti-ITGA4 polyclonal antibody (HPA074961)​

ITGA4/CD49d: Anti-ITGA4 polyclonal antibody (HPA074961)​

  • Selected interaction partners: VCAM
  • Involved in: cancer

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ITGA5/CD49e : Anti-ITGA5  monoclonal antibody (AMAb91449)​

ITGA5/CD49e : Anti-ITGA5  monoclonal antibody (AMAb91449)​

  • Selected interaction partners: ITGB1, ITGB3, ITGB5, FN1
  • Involved in: cancer growth/invasion

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ITGA6/CD49f: Anti-ITGA6 monoclonal antibody (AMAb91450)​

ITGA6/CD49f: Anti-ITGA6 monoclonal antibody (AMAb91450)​

  • Selected interaction partners: ITGB1, ITGB4
  • Involved in: laminin-binding. Cancer invasion/metastasis/stem cells.

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ITGA7/ITGA7: Anti-ITGA7 polyclonal antibody (HPA008427)​

ITGA7/ITGA7: Anti-ITGA7 polyclonal antibody (HPA008427)​

  • Selected interaction partners: ITGB1
  • Involved in: laminin-binding, cancer

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ITGA8/ITGA8: Anti-ITGA8 monoclonal antibody (AMAb91468)​

ITGA8/ITGA8: Anti-ITGA8 monoclonal antibody (AMAb91468)​

  • Selected interaction partners: ITGB1
  • Involved in: epithelial-to-mesenchymal transition.

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ITGAD/CD11D: Anti-ITGAD polyclonal antibody (HPA026786)​ 

ITGAD/CD11D: Anti-ITGAD polyclonal antibody (HPA026786)​ 

  • Selected interaction partners: ITGB2, ICAM3, VCAM1
  • Involved in: extracellular matrix organization, cell-cell adhesion, immune response

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ITGAE/CD103: Anti-ITGAE polyclonal antibody (HPA036313)​  

ITGAE/CD103: Anti-ITGAE polyclonal antibody (HPA036313)​  

  • Selected interaction partners: ITGB7, CDH1
  • Involved in: cancer

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ITGAM/CD11b: Anti-ITGAM monoclonal antibody (AMAb90911)​

ITGAM/CD11b: Anti-ITGAM monoclonal antibody (AMAb90911)​

  • Selected interaction partners: ITGB2, ICAM1
  • Involved in: immune system, monocytes

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ITGAV/CD51​: Anti-ITGAV polyclonal antibody (HPA004856)​  

ITGAV/CD51​: Anti-ITGAV polyclonal antibody (HPA004856)​  

  • Selected interaction partners: ITGB1, ITGB3, ITGB5, ITGB6, ITGB8
  • Involved in: cancer

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ITGA2B/CD41: Anti-ITGA2B polyclonal antibody (HPA031170)

ITGA2B/CD41: Anti-ITGA2B polyclonal antibody (HPA031170)

  • Selected interaction partners: ITGB3
  • Involved in: different, including metastasis

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ITGAX/CD11c: Anti-ITGAX monoclonal antibody (AMAb90915)​ 

ITGAX/CD11c: Anti-ITGAX monoclonal antibody (AMAb90915)​ 

  • Selected interaction partners: ITGB2
  • Involved in: cancer, leukemia

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IHC stainings of human placenta using Anti-ITGA6 (AMAb91450) and Anti-ITGB4 (AMAb91453).
IHC stainings of human placenta using (left) monoclonal antibody Anti-ITGA6 (AMAb91450) and (right) monoclonal antibody Anti-ITGB4 (AMAb91453) showing an identical pattern. The two integrins interact to form a laminin-binding Alpha6 Beta4 complex involved in cell migration and invasion.

Antibodies targeting integrin beta subunits

Our antibodies targeting the integrins are evaluated in one or more applications such as IHC, WB and ICC-IF. The table below shows selected antibodies for integrin beta subunits. For more details on each antibody, click the respective link below and visit the product page.

ITGB1/CD29: Anti-ITGB1/CD29 polyclonal antibody (HPA059297)

ITGB1/CD29: Anti-ITGB1/CD29 polyclonal antibody (HPA059297)

  • Selected interaction partners: ITGA1, ITGA2, ITGA3, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGA10, ITGA11, ITGAV
  • Involved in: laminin-binding, Cancer growth/invasion

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TGB2/CD18: Anti-ITGB2 polyclonal antibody (HPA016894)

TGB2/CD18: Anti-ITGB2 polyclonal antibody (HPA016894)

  • Selected interaction partners: ITGAL, ITGAD, ITGAM, ITGAX
  • Involved in: immune system

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ITGB3/CD61: Anti-ITGB3 monoclonal antibody (AMAb91470)

ITGB3/CD61: Anti-ITGB3 monoclonal antibody (AMAb91470)

  • Selected interaction partners: ITGA4, ITGA5, ITGA2B, ITGAV
  • Involved in: cancer

ITGB4/CD104: Anti-ITGB4 monoclonal antibody (AMAb91454)   

ITGB4/CD104: Anti-ITGB4 monoclonal antibody (AMAb91454)   

  • Selected interaction partners: ITGA3, ITGA6, SMAD2, SMAD3
  • Involved in: laminin-binding, Cancer growth/invasion

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ITGB5/ITGB5: Anti-ITGB5 polyclonal antibody (HPA001820)

ITGB5/ITGB5: Anti-ITGB5 polyclonal antibody (HPA001820)

  • Selected interaction partners: ITGA3, ITGA5, ITGAV
  • Involved in: cancer, cell adhesion, survival

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ITGB6/ITGB6: Anti-ITGB6 polyclonal antibody (HPA023626)

ITGB6/ITGB6: Anti-ITGB6 polyclonal antibody (HPA023626)

  • Selected interaction partners: ITGAV, MAPK1, FN1
  • Involved in: different diseases, cancer

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ITGB8/ITGB8: Anti-ITGB8 monoclonal antibody (AMAb91467) 

ITGB8/ITGB8: Anti-ITGB8 monoclonal antibody (AMAb91467) 

  • Selected interaction partners: ITGAV, RHEB, FN1
  • Involved in: cancer

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IHC staining of human bone marrow, lymph node, skeletal muscle and spleen using Anti-ITGB2 antibody HPA008877 (left) and Anti-ITGB2 antibody HPA016894 (right)
IHC staining of human bone marrow, lymph node, skeletal muscle and spleen using Anti-ITGB2 antibody HPA008877 (left) and Anti-ITGB2 antibody HPA016894 (right), as part of enhanced validation using independent antibodies, two antibodies targeting different parts of the same protein showing the same staining pattern (validation data pending release).
 IHC staining using monoclonal antibody Anti-ITGA3 (AMAb91446) showing strong immunoreactivity in lung and absence of staining in liver
Enhanced validation using an orthogonal method: IHC staining using monoclonal antibody Anti-ITGA3 (AMAb91446) showing strong immunoreactivity in lung and absence of staining in liver. RNA-Seq data for the same tissues below the image confirm the staining pattern (left). Western blot analysis in U-87 MG cells using the same antibody (right).