Integrins, Receptors for the Extracellular Matrix
Integrins are the principal receptors cells use to bind to the extracellular matrix. They constitute a family of transmembrane receptor proteins that play a crucial role in connecting the cytoskeleton to the extracellular matrix. This family is diverse, comprising 18 alpha and 8 beta subunits, which combine to form at least 24 distinct integrin heterodimers.
In-depth insights into the structure and function of integrins are explored in our White Paper. Additionally, the document introduces antibodies designed to specifically target various integrins, contributing to a comprehensive understanding of their roles in cellular processes.