Tumor Angiogenesis and Lymphoangiogenesis Markers

Angiogenesis is the lifelong formation of blood vessels from the existing vasculature and occurs throughout life in both health and disease. Lymphoangiogenesis, the formation of lymph vessels, plays a significant role in both tumor growth and metastasis.

Cancer cells differ from normal cells and benign tumor cells in their metabolic characteristics. Despite sufficient oxygen (O2) levels, aggressive cancers preferentially produce lactate. This distinguishing feature is known as the “Warburg effect”. The metabolic state of these tumors arises from changes in the tumor microenvironment, coupled among other things, to O2 availability. Ultimately, the increased growth and metabolic demand of malignant tumors lead to intra-tumoral hypoxia (lowered partial O2 pressure).

Cancer cells, like all living cells, strongly depend on an adequate supply of O2 and nutrients and the removal of waste products for their survival. Endogenous regulators of angiogenesis include, among others, growth factors, cytokines, proteases, protease inhibitors, and oncogenes. Recognition that control of angiogenesis (decreasing or inhibiting) could have therapeutic value has stimulated great interest during the past 40 years.

Staining of breast cancer using Anti-VWF antibody.
IHC staining of human breast cancer using the Anti-VWF antibody (AMAb90931) shows strong cytoplasmic positivity in endothelial cells.
Mechanisms in Cancer

Mechanisms in Cancer

Download our white paper to learn about the mechanisms in cancer and protein markers used in cancer research.

 

 

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Antibodies targeting tumor angiogenesis and lymphoangiogenesis markers

Atlas Antibodies offer a range of primary antibodies targeting tumor angiogenesis- and lymphoangiogenesis markers. Selected antibodies are listed below.

Anti-Akt1 monoclonal antibody (AMAb90834)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat 97%/97%

Anti-Akt1 monoclonal antibody (AMAb90835)

  • validated for WB
  • sequence identity mouse/rat 97%/97%

Anti-CD34 polyclonal antibody (HPA036722)

  • validated for IHC
  • sequence identity mouse/rat 63%/56%

Anti-EGFR monoclonal  antibody (AMAb90816)

  • validated for IHC, WB
  • sequence identity mouse/rat 91%/90%

Anti-ENG monoclonal  antibody (AMAb90925)

  • validated for IHC
  • sequence identity mouse/rat 66%/22%

Anti-EPAS1 polyclonal antibody (HPA031200)

  • validated for ICC-IF
  • sequence identity mouse/rat 95%/93%

Anti-FLT1  monoclonal antibody (AMAb90704)

  • validated for IHC, WB
  • sequence identity mouse/rat 80%/82%

Anti-FLT4 polyclonal antibody (HPA067906)

  • validated for IHC
  • sequence identity mouse/rat 75%/74%

Anti-GAPDH monoclonal antibody (AMAb91152)

  • validated for IHC, WB
  • sequence identity mouse/rat 94%/92%

Anti-GAPDH monoclonal antibody (AMAb91153)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 94%/92%

Anti-GAPDH polyclonal antibody (HPA040067)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 94%/92%

Anti-GAPDH polyclonal antibody (HPA061280)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat 92%/90%

Anti-HIF1A polyclonal antibody (HPA000907)

  • validated for ICC-IF
  • sequence identity mouse/rat 88%/87%

Anti-HIF1A polyclonal antibody (HPA001275)

  • validated for IHC
  • sequence identity mouse/rat 88%/87%

Anti-IDH1 monoclonal antibody (AMAb90578)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 95%/95%

Anti-IDH1 polyclonal antibody (HPA035248)

  • validated for IHC, WB
  • sequence identity mouse/rat 95%/95%

Anti-IDH1 polyclonal antibody (HPA057936)

  • validated for IHC, WB
  • sequence identity mouse/rat 95%/92%

Anti-IDH2 polyclonal antibody (HPA007831)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 95%/95%

Anti-LYVE1 polyclonal antibody (HPA042953)

  • validated for IHC, WB
  • sequence identity mouse/rat 63%/61%

Anti-NES monoclonal  antibody (AMAb90556)

  • validated for IHC, WB, ICC-IF
  • sequence identity mouse/rat 47%/42%

Anti-NES  polyclonal  antibody (HPA007007)

  • validated for IHC, WB
  • sequence identity mouse/rat 47%/42%

Anti-PDGFRB polyclonal  antibody (HPA028499)

  • validated for WB, ICC-IF
  • sequence identity mouse/rat 76%/76%

Anti-VEGFA polyclonal antibody (HPA069116)

  • validated for IHC
  • sequence identity mouse/rat 86%/88%

Anti-VEGFD polyclonal antibody (HPA027342)

  • validated for IHC, WB
  • sequence identity mouse/rat 86%/89%

Anti-VHL polyclonal  antibody (HPA031631)

  • validated for ICC-IF
  • sequence identity mouse/rat 49%/43%

Anti-vWF monoclonal antibody (AMAb90928)

  • validated for IHC, WB
  • sequence identity mouse/rat 80%/80%

Anti-vWF polyclonal antibody (HPA001815)

  • validated for IHC
  • sequence identity mouse/rat 80%/80%

Anti-vWF polyclonal antibody (HPA002082)

  • validated for IHC
  • sequence identity mouse/rat 82%/78%

Anti-vWF monoclonal antibody (AMAb90931)

  • validated for IHC, WB
  • sequence identity mouse/rat 80%/80%