Tumor Angiogenesis and Lymphoangiogenesis Markers

Angiogenesis is the lifelong formation of blood vessels from the existing vasculature and occurs throughout life in both health and disease. Lymphoangiogenesis, the formation of lymph vessels, plays a significant role in both tumor growth and metastasis.

Cancer cells differ from normal cells and benign tumor cells in their metabolic characteristics. Despite sufficient oxygen (O₂) levels, aggressive cancers preferentially produce lactate. This distinguishing feature is known as the “Warburg effect”. The metabolic state of these tumors arises from changes in the tumor microenvironment, coupled among other things, to O₂ availability. Ultimately, the increased growth and metabolic demand of malignant tumors lead to intra-tumoral hypoxia (lowered partial O₂ pressure).

Cancer cells, like all living cells, strongly depend on an adequate supply of O₂ and nutrients and the removal of waste products for their survival. Endogenous regulators of angiogenesis include, among others, growth factors, cytokines, proteases, protease inhibitors, and oncogenes. Recognition that control of angiogenesis (decreasing or inhibiting) could have therapeutic value has stimulated great interest during the past 40 years.

Staining of breast cancer using Anti-VWF antibody. — IHC staining of human breast cancer using the Anti-VWF antibody (AMAb90931) shows strong cytoplasmic positivity in endothelial cells.

Mechanisms in Cancer

Download our white paper to learn about the mechanisms in cancer and protein markers used in cancer research.

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Antibodies targeting tumor angiogenesis and lymphoangiogenesis markers

Atlas Antibodies offer a range of primary antibodies targeting tumor angiogenesis- and lymphoangiogenesis markers. Selected antibodies are listed below.

Anti-Akt1 monoclonal antibody (AMAb90834)

Validated for WB, ICC-IF
Sequence identity mouse/rat 97%/97%

Tumor Angiogenesis and Lymphoangiogenesis Markers

Mechanisms in Cancer

Antibodies targeting tumor angiogenesis and lymphoangiogenesis markers

Anti-Akt1 monoclonal antibody (AMAb90834)

Anti-Akt1 monoclonal antibody (AMAb90835)

Anti-CD34 polyclonal antibody (HPA036722)

Anti-EGFR monoclonal antibody (AMAb90816)

Anti-ENG monoclonal antibody (AMAb90925)

Anti-EPAS1 polyclonal antibody (HPA031200)

Anti-FLT1 monoclonal antibody (AMAb90704)

Anti-FLT4 polyclonal antibody (HPA067906)

Anti-GAPDH monoclonal antibody (AMAb91152)

Anti-GAPDH monoclonal antibody (AMAb91153)

Anti-GAPDH polyclonal antibody (HPA040067)

Anti-GAPDH polyclonal antibody (HPA061280)

Anti-HIF1A polyclonal antibody (HPA000907)

Anti-HIF1A polyclonal antibody (HPA001275)

Anti-IDH1 monoclonal antibody (AMAb90578)

Anti-IDH1 polyclonal antibody (HPA035248)

Anti-IDH1 polyclonal antibody (HPA057936)

Anti-IDH2 polyclonal antibody (HPA007831)

Anti-LYVE1 polyclonal antibody (HPA042953)

Anti-NES monoclonal antibody (AMAb90556)

Anti-NES polyclonal antibody (HPA007007)

Anti-PDGFRB polyclonal antibody (HPA028499)

Anti-VEGFD polyclonal antibody (HPA027342)

Anti-VHL polyclonal antibody (HPA031631)

Anti-vWF monoclonal antibody (AMAb90928)

Anti-vWF polyclonal antibody (HPA001815)

Anti-vWF polyclonal antibody (HPA002082)

Anti-vWF monoclonal antibody (AMAb90931)