White Papers and Brochures

Download and share our white papers, brochures and educational content on validation and antibody technologies, and discover our products for cancer, neuroscience, cell biology and stem cell research. 

Cancer

Atlas Antibodies in Cancer Research

Atlas Antibodies offer an extensive catalog of primary antibodies targeting a broad spectrum of markers relevant in cancer research and tailored for use on human and rodent tissue samples. Explore our selection of Triple A Polyclonals antibodies that are suitable markers for 17 human cancer types and learn about the top genes with favorable and unfavorable prognoses in cancer.

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Neuroendocrine Neoplasms Markers

Neuroendocrine neoplasms (NENs) constitute a group of tumors that derive from the sensory and secretory neuroendocrine cells of the diffuse endocrine system. There is an unmet need for accurate biomarkers that can be used for NEN diagnosis, prognosis and follow-up, therapy stratification, and evaluation of treatment response. In this white paper, we highlight our newly released PrecisA Monoclonals useful for the immunohistological profiling of NENs.

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Glioma Markers

Gliomas are one of the most aggressive and lethal solid tumors of the central nervous system. Despite the alarming numbers, the molecular pathogenetic mechanisms of gliomas are not yet fully elucidated. This white paper highlights the glioma proteome with a list of relevant genes with favorable and unfavorable prognostic values in glioma and focuses on the glioma tumor microenvironment that may provide helpful insights when developing novel therapeutic strategies.

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GPCR Markers for Cancer Research

G protein-coupled receptors play an essential role in different physiological functions and in cancer, contributing to cancer proliferation, angiogenesis, invasion, and metastasis. The pharmacological inhibition of GPCRs and their downstream targets is an opportunity to develop new, mechanism-based strategies for cancer prevention and treatment. In this whitepaper, we highlight the role of some selected GPCRs markers in cancer development and treatment.

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Cancer Stem Cell Markers

Cancer stem cells (CSCs) drive the tumor’s initiation, growth, and metastasis, and may cause relapse. Due to their importance, several biomarkers that characterize CSCs have been identified, allowing diagnostic, therapeutic, and prognostic predictions. In this white paper, we provide an overview of the most prominent CSC markers, focusing on solid cancers and hematological cancers.

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Tumor Microenvironment and Cancer Immunity

The tumor microenvironment (TME) is the environment around a tumor that profoundly influence tumor progression and metastatic processes. In this White Paper, you can read more about TME and cancer immunity markers.

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Epithelial-to-Mesenchymal Transition Markers

The Epithelial to Mesenchymal Transition (EMT) antibody marker panel is a collection of mouse monoclonals targeting key EMT markers for cell junctions, cytoskeletal changes, transcription regulation, and migration/motility. This White Paper explains the design, development, and validation of the EMT marker antibodies.

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SOX Family

SOX proteins make up a family of high-mobility group (HMG) domain transcription factors implicated in a variety of physiological and pathological processes, including development, cell reprogramming, and tumorigenesis. So far, 20 different SOX genes have been discovered. This White Paper explains the role of the SOX family of proteins and presents antibodies targeting the SOX family members. 

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Atlas Antibodies in Colorectal Cancer Research

A large number of our antibodies are relevant for scientists studying colorectal cancer. In this brochure, you can find antibodies related to the field of colorectal cancer research together with publication references.

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Atlas Antibodies in Breast Cancer Research

Our antibodies are used by scientists working to understand breast cancer. In this brochure, you can find antibodies related to the field of breast cancer research together with publication references. 

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ATRX, a Marker for Glioma

This white paper presents the useful glioma marker ATRX and suitable co-markers IDH1 and GFAP. You will also find information about antibodies targeting these proteins.

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Oncology Biomarkers

Together with our research partners in the Human Protein Atlas project, we are in a unique position to perform antibody-based biomarker discovery. This white paper provides an overview of a few selected biomarkers. 

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Mechanisms in Cancer

This white paper presents different mechanisms in cancer, including cell cycle,  cell death, tumor proliferation, tumor angiogenesis, and metastasis. In addition, you will find selected primary antibodies targeting protein markers involved in the respective cancer processes.

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Neuroscience

Atlas Antibodies in Neuroscience

Neuroscience studies the nervous system the disorders and injuries that affect its functioning. We offer a large catalog of primary monoclonal and polyclonal antibodies targeting a wide spectrum of markers relevant in neuroscience research and tailored for use on human and rodent tissue samples. Our antibodies are highly validated and show high specificity and selectivity for their target proteins.

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Glioma Markers

Gliomas are one of the most aggressive and lethal solid tumors of the central nervous system. Despite the alarming numbers, the molecular pathogenetic mechanisms of gliomas are not yet fully elucidated. This white paper highlights the glioma proteome with a list of relevant genes with favorable and unfavorable prognostic values in glioma and focuses on the glioma tumor microenvironment that may provide helpful insights when developing novel therapeutic strategies.

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Neuroinflammation

In this white paper, we discuss the role of microglia, oligodendrocytes, and astrocytes in the neuroinflammatory processes highlighting the relevant antibody markers with a particular focus on multiple sclerosis.

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Cortical Layer Markers

The cerebral cortex is the part of the human brain that undergoes the most profound evolutional changes and serves as a substrate for the higher cognitive functions. Learn about development and characteristics of cortical layers and about common markers for the different layers.

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ATRX, a Marker for Glioma

This white paper presents the useful glioma marker ATRX and suitable co-markers IDH1 and GFAP. You will also find information about antibodies targeting these proteins.

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Neural Stem Cell Markers

Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. In this White Paper, you can learn about neural stem cell markers in the mammalian brain.

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Stem Cells

Cancer Stem Cell Markers

Cancer stem cells (CSCs) drive the tumor’s initiation, growth, and metastasis, and may cause relapse. Due to their importance, several biomarkers that characterize CSCs have been identified, allowing diagnostic, therapeutic, and prognostic predictions. In this white paper, we provide an overview of the most prominent CSC markers, focusing on solid cancers and hematological cancers.

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Stem Cells the Source of Life

Stem cells are the cells that have a capacity for self-renewal and differentiation into other cell types. Two major stem cell types are present in mammals, embryonic stem cells and adult stem cells. In this White Paper, you can learn about the different types of stem cells, which protein markers are used to identify them and see which antibodies can be used to detect these proteins.

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Neural Stem Cell Markers

Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. In this White Paper, you can learn about neural stem cell markers in the mammalian brain.

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Mesenchymal Stem Cell Markers

Mesenchymal stem cells (MSCs) are tissue stem cells. They are ‘multipotent’, implying that they can differentiate into more than one cell type in the body. In this White Paper, you can learn about the different mesenchymal stem cell markers.

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Cell Biology

Centriolar Satellite Markers

Centriolar satellites are membraneless granules that localize and move around centrosomes and cilia. Atlas Antibodies offers numerous markers targeting centriolar satellites proteins, some of which are highlighted in this white paper.

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Histones

Histones are the proteins that provide structural support for a chromosome. Eukaryotic cells use histone proteins to store DNA in the form of chromatin. Chromatin consists of tightly packed nucleosomes, where each nucleosome particle is built of an octamer with pairs of the four core histones H3, H4, H2A, and H2B. In addition, the linker histone H1 links the nucleosomes together and plays a role in modifying chromatin density and folding. This white paper explains the role of histones and lists our PrecisA Monoclonal antibodies targeting histones validated for IHC, WB, and ICC-IF. 

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Organelle Markers

This White Paper explains the design, development, and validation of the organelle marker antibodies and describes how subcellular localization studies can be performed. The markers can be used as references to stain and confirm the location of the protein of interest. 

 

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Integrins, Receptors for the Extracellular Matrix

Integrins are a family of transmembrane receptor proteins connecting the cytoskeleton and extracellular matrix. There are 18 alpha and 8 beta subunits, forming at least 24 distinct integrin heterodimers. This White Paper explains the function and structure of integrins and presents antibodies specifically targeting the different integrins.

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Laminin Markers Panel

The antibodies in the Laminin Markers panel are designed to identify specific laminin subunits present in a tissue of interest to further understand the roles and expression patterns of different laminins. This White Paper explains the design, development, and validation of the laminin marker antibodies and includes one example of how to perform the verification of the subunit composition of laminins in tissue using multiplexed IHC with antibodies from the panel. 

 

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Applications & Validation

Enhanced Validation of Antibodies

This white paper provides an overview on how our antibodies are characterized and validated. Learn about antibody characterization and strategies for antibody validation. 

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Immunohistochemistry in Human Tissues

This paper presents the immunohistochemistry application, and how the tissue microarrays allow for large scale protein expression profiling within the Human Protein Atlas project. You can also read about how immunohistochemistry is used for subcellular protein profiling.

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Immunofluorescence in Cell Lines

Subcellular protein localization studies are crucial in elucidating protein function and interaction. We have characterized the subcellular protein localization in 30 organelles using immunofluorescence in cell lines. Read more about it.

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Tissue Expression Profiling using Triple A Polyclonals

Each Triple A Polyclonal is analyzed in 44 normal human tissues and the 20 most common cancers using IHC. All proteins expression profiles are conveniently searchable online on the Human Protein Atlas portal. This White Paper shows how our antibodies are used for exploring the whole human body, and highlights selected publications published in high impact journals.

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Loading Controls

This White Paper offers advice on how to use loading control antibodies for your Western blot experiment and what to consider when choosing a loading control. 

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In situ PLA - Application Example

The white paper demonstrates how the Triple A Polyclonals and PrecisA Monoclonals can be used for the detection of protein-protein interactions in human tissues in situ using a powerful PLA technique. Applications examples include Emerin-Lamins interactions in the nuclear membrane and interactions of E-cadherin and beta-catenin in the epithelial cell membrane. 

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